How you’ll spend your day
Perform Polymorph screening as per guideline.
Follow cGMP Documentation and EHS compliance at workplace
Perform Virtual and Experimental Screen and evaluate all literature that relates to solid-state issues.
Screen new forms by performing stress tests and File ASAP new forms in patent application
Analyze laboratory samples by XRD, DSC, TGA and other characterization techniques.
Assess kinetic stability and interconversions and produce scheme of all polymorphic transitions
Produce solubility curves of different polymorphs and assess thermodynamic stability relationships
Develop detection methods to assess polymorphic purity and monitor in the laboratory samples
Support the development of the crystallization process with full characterization
Monitoring stability and physical properties of micronized/milled materials
Perform calibration, method development, method validation, and troubleshooting using various instruments like PXRD, DSC, TGA and Particle size analyzer
Knowledge of various regulatory guidelines w.r.t. method development, product development, and documentation.
Your experience and qualifications
Qualification: MSc Chemistry / B Tech (Chemical Engineer)
Experience:
1-5 years of experience in relevant industry and profile
Experience with quantum chemistry, molecular modeling,
Programming in Python, R, or MATLAB.
Experience with machine learning (ML) algorithms for chemical data (e.g., regression, clustering, neural networks).
Familiarity with chemoinformatics libraries (e.g., RDKit, Open Babel).
Knowledge of data visualization (Matplotlib, Seaborn, Plotly).
Molecular docking and simulations (e.g., AutoDock, GROMACS, Gaussian).
Use of AI/ML models for material science or drug discovery.
Polymorph Screening experience
Analyze laboratory samples by XRD, DSC, TGA and other characterization techniques
Follow cGMP Documentation and EHS compliance at workplace
Support the development of the crystallization process with full characterization
Internships or work experience in pharmaceutical, chemical, or biotech industries
