The Senior scientist will report to the Director, Discovery and Validation in the Research and Drug Discovery group.
The candidate will be responsible for leading all protein science activities and managing antibodies developability activities toward antibody lead selection.
The candidate will lead multidisciplinary activities in the field of protein science ranging from early R&D development through pre-clinical validation, contribution his/her expertise to all projects in the pipeline.
The candidate is expected to demonstrate creative/out of the box thinking, propose original solutions to complex problems, conceive new scientific hypotheses that support drug discovery effort, establish new capabilities, and provide scientific leadership to biochemical characterization of protein and antibodies in the group. Managing all protein science related activities and execute protein related characterization.
Develop different biochemical assays for antibody characterization
Perform different biochemical assays for antibody characterization (Western blot, ELISA)
Perform and lead antibody and protein production in house
Establish SPR capabilities in house
Collaborate with team members to ensure timely progress of research projects according to pipeline prioritization
The candidate will be responsible for leading all protein science activities and managing antibodies developability activities toward antibody lead selection.
The candidate will lead multidisciplinary activities in the field of protein science ranging from early R&D development through pre-clinical validation, contribution his/her expertise to all projects in the pipeline.
The candidate is expected to demonstrate creative/out of the box thinking, propose original solutions to complex problems, conceive new scientific hypotheses that support drug discovery effort, establish new capabilities, and provide scientific leadership to biochemical characterization of protein and antibodies in the group. Managing all protein science related activities and execute protein related characterization.
Develop different biochemical assays for antibody characterization
Perform different biochemical assays for antibody characterization (Western blot, ELISA)
Perform and lead antibody and protein production in house
Establish SPR capabilities in house
Collaborate with team members to ensure timely progress of research projects according to pipeline prioritization
Requirements:
PhD in Life Sciences with minimum 6 years of experience in the biotech industry
Highly experienced in protein engineering, protein expression and purification a must
Highly experienced in protein analytical methods Biacore, HPLC a must
Highly experience in biochemical technologies ELISA, Western blot a must
Knowledgeable in protein- protein interaction a must
Knowledgeable in monoclonal antibody discovery highly desired
Experienced in cell culture technologies an advantage
Over expression systems (lentivirus, , transfections etc.) including single clone generation and characterization, cell soring
knock-down/knock out technologies (si/shRNA, CRISPR)
Experience in molecular biology methods an advantage
Experience in cell based in vitro assays an advantage
Experience in FACS staining
Excellent written and verbal communication skills (English)
Ability to prioritize and manage multiple projects and activities
Ability to work independently; proactively address issues and troubleshoot problems
PhD in Life Sciences with minimum 6 years of experience in the biotech industry
Highly experienced in protein engineering, protein expression and purification a must
Highly experienced in protein analytical methods Biacore, HPLC a must
Highly experience in biochemical technologies ELISA, Western blot a must
Knowledgeable in protein- protein interaction a must
Knowledgeable in monoclonal antibody discovery highly desired
Experienced in cell culture technologies an advantage
Over expression systems (lentivirus, , transfections etc.) including single clone generation and characterization, cell soring
knock-down/knock out technologies (si/shRNA, CRISPR)
Experience in molecular biology methods an advantage
Experience in cell based in vitro assays an advantage
Experience in FACS staining
Excellent written and verbal communication skills (English)
Ability to prioritize and manage multiple projects and activities
Ability to work independently; proactively address issues and troubleshoot problems
This position is open to all candidates.
